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Given its autosomal recessive inheritance, consanguinity among carrier couples is considered as the main risk factor for PKU [3].

This review aims to investigate the prevalence and incidence of PKU in Arab countries, Turkey, and Iran, which share similar culture and customs.

Newborn screening is the principal population-based public health screening program which is being practiced at present across the globe [7].

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The incidence of PKU varies among ethnic groups and geographic regions worldwide [9].

For example, Caucasians are effected at a rate of 1 : 10,000 birth in the United States [10].

Deficiency of BH4 is a rare disorder that changes the levels of various substances in the body, including phenylalanine [3].

Clinical manifestations of BH4 deficiency include intellectual disability, neurological deterioration, difficulty swallowing, movement disorders, behavioral problems, seizures, and an incapability to control body temperature.

Each airline maintains its own individual style and cultural identity, bringing the richness of diversity and multiculturalism to the alliance.