When your program can't connect to the server, it can become out of date and may miss detection of the ever-increasing amount of malware lurking online.If you've determined that your Internet connection is functioning properly, focus your troubleshooting on the program itself.
Your MSE program may not be updating properly due to improper installation or corrupted system files.
If your various troubleshooting attempts haven't been successful, completely uninstall and reinstall MSE to ensure a clean copy of all program files.
ISA Server 2000 reached End of Life on 12 April 2011., and improved reporting and management features.
The rules based configuration was also considerably simplified over ISA Server 2000 version.
For example, some organizations use ISA Server 2004 to publish their Microsoft Exchange Server services such as Outlook Web Access (OWA), Outlook Mobile Access (OMA) or Active Sync.